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Diabetes Complications Treatment You might hear your healthcare team talk about two types of diabetes complications: serious ones that build up over time called chronic complications and ones that can happen at any time called acute complications. Kidney problems (nephropathy) Diabetes can cause damage to your kidneys over a long period of time making it harder to clear extra fluid and waste from your body. This is caused by high blood sugar levels and high blood pressure. It is known as diabetic nephropathy or kidney disease.