Diabetes Mellitus is a chronic progressive spectrum of diseases which involved almost every organ of the body. It's one of the most common causes of premature aging. In a natural course of the uncontrolled Diabetes the organs like Kidneys (Nephropathy/ Chronic Kidney Disease), Eyes ( Retinopathy/ Early Cataract) , Nervous system (Neuropathy) , Cardiovascular system ( Coronary Artery Disease, Ischemic Heart Disease, Cardiomyopathy), Skin ( Acanthosis, pigmentation) , Nails ( fungal infections), Gastro-intestinal system (Gastroparesis, Altered bowel) , Sexual health (Erectile dysfunction , low libido, anorgasmia) and almost all other organs are involved. The current trends of managing Diabetes focuses on tight blood sugar control by medications, life style modification, exercise, dietary modification, sleep management and stress reduction. Now we have started to look in the other potential hormonal and metabolic implications of Diabetes and started focusing on fixing them. Once diagnosed with Diabetes one should not leave hope. The current medical world is working very hard to give array of hope to people living with diabetes.