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Diabetes Cause Kidney Disease As mentioned above, the small blood vessels (capillaries) within the kidney acts as a filter. As blood flows through the blood vessels, small molecules like waste products squeeze through the holes. These waste products become a part of the urine. Like protein and red blood cells, essential substances are too big to go through the holes within the filter and stay within the blood. High levels of blood sugar seen in diabetic patients create troubles in the filtering capacity of the kidney. To begin with, they create the kidneys to filter more blood. After a few years, the kidneys start to sink to the heavy workload. They begin to leak, and essential protein is lost in the urine. Initially, the quantity of protein excreted is a small amount, but soon after, it increases. When the kidney starts losing protein, several treatments may keep kidney disease from getting worse. But if kidney disease is diagnosed at the stage where larger amounts of protein are excreted within the urine, the end-stage renal disease or ESRD usually develops. In time, the strain of overwork causes the kidneys to lose their filtering ability. Waste products then start to build up in the blood. Finally, the kidneys fail. This failure, ESRD, is extremely serious. An individual with ESRD must have a kidney transplant or possess the blood filtered by a machine (dialysis).